United States - Telomere length and chronic graft-versus-host in hematopoietic cell transplant

Description

Added: Aug 16, 2019 5:23 pm

The National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Clinical Genetics Branch (CGB) plans to procure laboratory services for telomere length measurement using the 6-panel flow FISH assay from Repeat Diagnostics Inc. of 309-267 West Esplanade Ave., North Vancouver, BC V7M 1A5 Canada.

This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and will be made pursuant to the authority in FAR 13.106-1 (b)(1)(i) using simplified acquisition procedures for commercial acquisitions. The response close date of this notice for this requirement is in accordance with FAR 5.203(a)(1). The North American Industry Classification System code is 541990 and the business size standard is $15.0M. Commercial terms and conditions, FAR 52.212-4 and 52.212-5, shall apply to any acquisition related to this notice. FAR 52.202-24 and FAR 52.202-25 are also applicable.
BACKGROUND:
Telomeres consist of long TTAGGG nucleotide repeats at chromosome ends and protein complexes that are essential for maintaining chromosomal stability. They shorten with each cell division; therefore, telomere length is a marker of cellular age, and replicative history. Recent studies in severe aplastic anemia have shown that donor telomere length was associated with patient survival after hematopoietic cell transplantation (HCT). Chronic graft-versus-host disease (cGVHD) is a severe life-threatening complication of HCT. In this study, NCI intends to evaluate the relationship between telomere length and cGVHD etiology and progression.
SCOPE:
This requirement is part of NCI investigators' effort to evaluate the role of donor telomere length in outcomes after HCT. NCI investigators will use the CLIA-certified flow FISH assay to precisely quantify changes in telomere length after HCT in patients with and without cGVHD using 392 samples from 90 patients who were enrolled in the longitudinal study of immune-mediated disorders biomarker.
Repeat Diagnostics is the only known laboratory that can perform the required measurements due to an on-going study and the need for continuity of results. This requirement continues the effort begun under Purchase Order HHSN261201800718P. Repeat Diagnostics holds US CLIA-certification and can perform the 6-panel telomere length flow-FISH assay. For this requirement, the Contractor shall:
• Measure telomere length in provided samples using flow FISH 6-panel assay
• Provide the NCI a data file containing:
1. Telomere length absolute measurement for each sample by all cell types
2. Telomere length percentile in relation to reference population
This notice is not a request for competitive quotation. However, if any interested party, especially small business believes it can meet the above requirement, it may submit a capability statement for the Government to consider. The response and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 12:00 PM ET, on August 26, 2019. All responses and questions must be via email to Miguel Diaz, Contracting Officer at miguel.diaz@nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must be registered and have valid certification through SAM.GOV and have Representations and Certifications filled out. Reference: 75N91019Q00146 on all correspondence.

Opportunity closing date

26 August 2019

Value of contract

to be confirmed