Germany - Mass spectrometer

Description

Procurement of a high-resolution QTOF mass spectrometer system.
The tender is for the supply of a high resolution QTOF mass spectrometer system for the Borstel Research Centre consisting of:1. Compact high resolution benchtop QTOF mass spectrometer system Bench-top electrospray quadrupole time-of-flight mass spectrometer for measurements of accurate masses and isotopic patterns with high au[input]nt resolution in both MS and MS/MS modes. Includes ESI- Ion funnel source, hyperbolic high power quadrupole, high transmission collision cell for CID, TOF analyzer with temperature compensation, electronics, syringe pump, data system with 5 Ghz 10 bit digitizer and 24'' LCD monitor, current software for HPLC and MS control, data acquisition and processing. The system shall include the following performance requirements:- Benchtop ESI quadrupole time-of-flight mass spectrometer with small footprint (less than or equal to 65 x 95 cm)- ESI sprayer grounded for ease of use at e.g. CE- Ion funnel technology- Analog signal acquisition for lifelike imaging of isotope pattern- Digitizer 5Gsample/sec. ADC with 50 Gbit/sec- 10 bit ADC for high quantitative dynamic range- Acquisition rate up to 50Hz- Tof mass range: min. 20 - 40,000 m/z- Mass accuracy (MS and MS/MS): < 1 ppm (int. calibration) < 2ppm (ext. calibration) in wide dynamic range independent of sample concentration.- hrXIC, highly accurate extracted ion traces, at better than +/- 1.5 mDa width and stability over a typical LC peak- One calibration for MS and MS/MS measurements- Resolution: > 30,000 @ m/z 1222 at 50 Hz acquisition rate without loss of sensitivity- Dynamic range (intrascan): ≥ 5 orders of magnitude- Precursor selection: up to 3000 m/z- Sensitivity for reserpine (MS): 1 pg S/N > 100:1 RMS at full resolution; with ion booster (optional): reserpine 100 fg, S/N>100:1 RMS- Sensitivity for Glu-fibrinopeptide B (MS/MS): 2.5 fmol S/N > 50:1 RMS2. High pressure HPLC systems Flow range 1 µl to 5 ml /min; active backflush, mixer volume 35 µl, automatic purge and prime via internal pump, automatic adjustment of solvent compressibility, internal 2-channel degasser and eluent switching valve for selection of two eluents per pump module. Back pressures up to 1300 bar. Temperature controlled (from 4-40°C) autosampler with space for 2 x 96 (384) microtiter plates or 108 standard vials (2 ml), carryover must be <0.001%; injection modes: full loop, partial loop fill and µL pickup mode, includes elute column oven (heatable to +90°C in 1 degree increments), optional high pressure column switching valve (1000 bar) to run up to 6 columns up to 30 cm long, coolable.3. system for uninterruptible power supply 4. metabolomics evaluation software, incl. powerful workstation5. MS library6. RP column kit for metabolomics workflows7. CE Declaration of Conformity

Opportunity closing date

17 January 2022

Value of contract

to be confirmed